Onwuzurike is out for the 2025 season, leaving Detroit without a key interior disruptor. That absence increases reliance on Reader, Williams and Lopez to anchor the middle. The defensive tackle room is built for depth, but the missing starter challenges run defense and interior pressure early in the year.

Onwuzurike is on the Lions’ PUP list, increasing interior run-guard concerns. If he’s limited, Green Bay’s inside runs and play-action could be more effective early. His status shapes Detroit’s run defense and the game’s tempo, particularly if McNeil or Paschal are sidelined too.

Onwuzurike’s health and return to form are a focal point for Lions’ interior rush and overall defense depth, shaping fantasy expectations for Detroit’s front and related DST value.

Levi Onwuzurike suffered a season-ending ACL injury, costing Detroit a stabilizing interior defender. His absence intensifies early-season pressure on the Lions' interior line and can shift run-stopping duties to backups while impacting the pass rush from the middle.

Onwuzurike’s ACL injury sidelines him for the season, accelerating Williams’ rise and heightening Detroit’s need for interior disruption. The absence exposes Williams to more reps and responsibilities as the Lions navigate the early weeks without him.